I) Introduction
II) Elementary probability theory:
a. Probability model
b. Additivity of probabilities for disjunct events
c. Independence – multiplication
d. Conditional probabilities
 

III) Elementary population genetics:
a. Frequencies – gene (allele) frequencies, genotype frequencies, phenotype frequencies, haplotype frequencies
b. Hardy – Weinberg equilibrium IV) Simple paternity case – Trio a. Hypotheses b. Calculation of X and Y
c. Likelihood ratio Y/X and paternity index PI
d. Posterior probability W, Bayes Theorem
 

V) Practical problems from population genetics:
a. Estimation of gene frequencies from a sample
b. Testing of Hardy Weinberg Equilibrium
VI) Simple paternity testing by computer:
a. Installation of the software W-VAT on the laptops
b. Trio cases / Duo cases
 

I) Complex cases 1:
a. Deficiency case with grandparents
b. General deficiency cases – complex pedigrees, multiple hypotheses
 

II) Complex cases 2:
a. Y-chromosomal markers, X-chromosomal markers
b. Possible mutations, possible silent alleles
 

III) Solving complex cases with the software:
a. Complex pedigrees
b. X-chrom. / Y-chrom. Markers
c. Possible mutations

Please bring your own problems to the workshop !!!
 

 IV) Final discussion of general questions and problems in the plenum